The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations

AIMS/HYPOTHESIS: We examined the contribution of rare HNF1A variants to type 2 diabetes risk and age of diagnosis, and the extent to which their impact is affected by overall genetic susceptibility, across three ancestry groups. METHODS: Using exome sequencing data of 160,615 individuals of the UK B...

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Detalles Bibliográficos
Autores principales: Stalbow, Lauren A., Preuss, Michael H., Smit, Roelof A. J., Chami, Nathalie, Bjørkhaug, Lise, Aukrust, Ingvild, Gloyn, Anna L., Loos, Ruth J. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729131/
https://www.ncbi.nlm.nih.gov/pubmed/36216889
http://dx.doi.org/10.1007/s00125-022-05806-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729131/
https://www.ncbi.nlm.nih.gov/pubmed/36216889
http://dx.doi.org/10.1007/s00125-022-05806-2

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