An in silico method to assess antibody fragment polyreactivity

Antibodies are essential biological research tools and important therapeutic agents, but some exhibit non-specific binding to off-target proteins and other biomolecules. Such polyreactive antibodies compromise screening pipelines, lead to incorrect and irreproducible experimental results, and are ge...

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Detalles Bibliográficos
Autores principales: Harvey, Edward P., Shin, Jung-Eun, Skiba, Meredith A., Nemeth, Genevieve R., Hurley, Joseph D., Wellner, Alon, Shaw, Ada Y., Miranda, Victor G., Min, Joseph K., Liu, Chang C., Marks, Debora S., Kruse, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729196/
https://www.ncbi.nlm.nih.gov/pubmed/36477674
http://dx.doi.org/10.1038/s41467-022-35276-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729196/
https://www.ncbi.nlm.nih.gov/pubmed/36477674
http://dx.doi.org/10.1038/s41467-022-35276-4

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