Water-soluble trehalose glycolipids show superior Mincle binding and signaling but impaired phagocytosis and IL-1β production

The tremendous potential of trehalose glycolipids as vaccine adjuvants has incentivized the study of how the structures of these ligands relate to their Mincle-mediated agonist activities. Despite this, structure-activity work in the field has been largely empirical, and less is known about how Minc...

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Detalles Bibliográficos
Autores principales: Manthrirathna, M. A. Thathsaranie P., Dangerfield, Emma M., Ishizuka, Shigenari, Woods, Aodhamair, Luong, Brenda S., Yamasaki, Sho, Timmer, Mattie S. M., Stocker, Bridget L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729344/
https://www.ncbi.nlm.nih.gov/pubmed/36504717
http://dx.doi.org/10.3389/fmolb.2022.1015210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729344/
https://www.ncbi.nlm.nih.gov/pubmed/36504717
http://dx.doi.org/10.3389/fmolb.2022.1015210

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