DNMT1/PKR double knockdowned HepG2 (HepG2-DP) cells have high hepatic function and differentiation ability

HepG2 cells are widely used as a human hepatocytes model, but their functions, including drug metabolism, are inferior to primary hepatocytes. We previously reported that the hepatic gene expressions in HepG2 cells were upregulated by treatment with zebularine, which is an inhibitor of DNA methylati...

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Detalles Bibliográficos
Autores principales: Tanaka-yachi, Rieko, Aizawa, Kazuko, Shimizu, Kie, Akutsu, Hidenori, Nakamura, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729623/
https://www.ncbi.nlm.nih.gov/pubmed/36476676
http://dx.doi.org/10.1038/s41598-022-25777-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729623/
https://www.ncbi.nlm.nih.gov/pubmed/36476676
http://dx.doi.org/10.1038/s41598-022-25777-z

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