Accurate protein stability predictions from homology models

Calculating changes in protein stability (ΔΔG) has been shown to be central for predicting the consequences of single amino acid substitutions in protein engineering as well as interpretation of genomic variants for disease risk. Structure-based calculations are considered most accurate, however the...

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Detalles Bibliográficos
Autores principales: Valanciute, Audrone, Nygaard, Lasse, Zschach, Henrike, Maglegaard Jepsen, Michael, Lindorff-Larsen, Kresten, Stein, Amelie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729920/
https://www.ncbi.nlm.nih.gov/pubmed/36514339
http://dx.doi.org/10.1016/j.csbj.2022.11.048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729920/
https://www.ncbi.nlm.nih.gov/pubmed/36514339
http://dx.doi.org/10.1016/j.csbj.2022.11.048

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