Structural characterization and conformational dynamics of alpha-1 antitrypsin pathogenic variants causing alpha-1-antitrypsin deficiency

Background: Alpha-1 antitrypsin deficiency (A1ATD) is a progressive lung disease caused by inherited pathogenic variants in the SERPINA1 gene. However, their actual role in maintenance of structural and functional characteristics of the corresponding α-1 anti-trypsin (A1AT) protein is not well chara...

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Detalles Bibliográficos
Autores principales: Shaik, Noor Ahmad, Saud Al-Saud, Najla Bint, Abdulhamid Aljuhani, Thamer, Jamil, Kaiser, Alnuman, Huda, Aljeaid, Deema, Sultana, Nasreen, El-Harouni, Ashraf AbdulRahman, Awan, Zuhier Ahmed, Elango, Ramu, Banaganapalli, Babajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730039/
https://www.ncbi.nlm.nih.gov/pubmed/36504721
http://dx.doi.org/10.3389/fmolb.2022.1051511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730039/
https://www.ncbi.nlm.nih.gov/pubmed/36504721
http://dx.doi.org/10.3389/fmolb.2022.1051511

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