Glucocorticoid receptor hypersensitivity enhances inflammatory signaling and inhibits cell cycle progression in porcine PBMCs

The consequences of glucocorticoid receptor (GR) hypersensitivity during infection have so far received little attention. We previously discovered that a natural gain-of-function Ala610Val substitution in the porcine GR aggravates response of pigs to lipopolysaccharide (LPS)-induced endotoxemia, whi...

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Detalles Bibliográficos
Autores principales: Li, Zhiwei, Hadlich, Frieder, Wimmers, Klaus, Murani, Eduard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730246/
https://www.ncbi.nlm.nih.gov/pubmed/36505401
http://dx.doi.org/10.3389/fimmu.2022.976454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730246/
https://www.ncbi.nlm.nih.gov/pubmed/36505401
http://dx.doi.org/10.3389/fimmu.2022.976454

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