TGFβ-derived immune modulatory vaccine: targeting the immunosuppressive and fibrotic tumor microenvironment in a murine model of pancreatic cancer

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is associated with very poor survival, making it the third and fourth leading cause of all cancer-related deaths in the USA and European Union, respectively. The tumor microenvironment (TME) in PDAC is highly immunosuppressive and desmoplastic, whi...

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Detalles Bibliográficos
Autores principales: Perez-Penco, Maria, Weis-Banke, Stine Emilie, Schina, Aimilia, Siersbæk, Majken, Hübbe, Mie Linder, Jørgensen, Mia Aaboe, Lecoq, Inés, Lara de la Torre, Lucia, Bendtsen, Simone Kloch, Martinenaite, Evelina, Holmström, Morten Orebo, Madsen, Daniel Hargbøl, Donia, Marco, Ødum, Niels, Grøntved, Lars, Andersen, Mads Hald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730419/
https://www.ncbi.nlm.nih.gov/pubmed/36600556
http://dx.doi.org/10.1136/jitc-2022-005491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730419/
https://www.ncbi.nlm.nih.gov/pubmed/36600556
http://dx.doi.org/10.1136/jitc-2022-005491

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