Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors

BACKGROUND: Inactivation of the Hippo pathway promotes Yap nuclear translocation, enabling execution of a transcriptional program that induces tissue growth. Genetic lesions of Hippo intermediates only identify a minority of cancers with illegitimate YAP activation. Yap has been implicated in resist...

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Detalles Bibliográficos
Autores principales: Garcia-Rendueles, Maria E. R., Krishnamoorthy, Gnana, Saqcena, Mahesh, Acuña-Ruiz, Adrian, Revilla, Giovanna, de Stanchina, Elisa, Knauf, Jeffrey A., Lester, Rona, Xu, Bin, Ghossein, Ronald A., Fagin, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730579/
https://www.ncbi.nlm.nih.gov/pubmed/36476495
http://dx.doi.org/10.1186/s12943-022-01676-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730579/
https://www.ncbi.nlm.nih.gov/pubmed/36476495
http://dx.doi.org/10.1186/s12943-022-01676-9

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