The A-to-I editing of KPC1 promotes intrahepatic cholangiocarcinoma by attenuating proteasomal processing of NF-κB1 p105 to p50

BACKGROUND: Aberrant RNA editing of adenosine-to-inosine (A-to-I) has been linked to multiple human cancers, but its role in intrahepatic cholangiocarcinoma (iCCA) remains unknown. We conducted an exome-wide investigation to search for dysregulated RNA editing that drive iCCA pathogenesis. METHODS:...

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Detalles Bibliográficos
Autores principales: Gao, Chengming, Zhou, Guangming, Shi, Jie, Shi, Peipei, Jin, Liang, Li, Yuanfeng, Wang, Xiaowen, Liao, Song, Yan, Han, Wu, Junjie, Lu, Yiming, Zhai, Yun, Zhang, Jinxu, Zhang, Haitao, Zhang, Hongxing, Yang, Chenning, Cao, Pengbo, Cheng, Shuqun, Zhou, Gangqiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730630/
https://www.ncbi.nlm.nih.gov/pubmed/36476255
http://dx.doi.org/10.1186/s13046-022-02549-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730630/
https://www.ncbi.nlm.nih.gov/pubmed/36476255
http://dx.doi.org/10.1186/s13046-022-02549-1

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