Cargando…

Clinical application of RUBCN/SESN2 mediated inhibition of autophagy as biomarkers of diabetic kidney disease

BACKGROUND: Deregulated autophagy in diabetes has been a field of many experimental studies recently. Impaired autophagy in diabetic kidneys orchestrates every step of diabetic nephropathy (DN) pathogenesis. This study aimed to evaluate three autophagy regulators; RUBCN, mTOR, and SESN2 as clinicall...

Descripción completa

Detalles Bibliográficos
Autores principales:	Watany, Mona M., El-Horany, Hemat E., Elhosary, Marwa M., Elhadidy, Ahmed A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730641/ https://www.ncbi.nlm.nih.gov/pubmed/36476132 http://dx.doi.org/10.1186/s10020-022-00580-8

Ejemplares similares

Empagliflozin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats by Modulating Sesn2/AMPK/Nrf2 Signaling and Targeting Ferroptosis and Autophagy
por: El-Horany, Hemat El-Sayed, et al.
Publicado: (2023)

Targeting Oxidative Stress, Autophagy, and Apoptosis by Quercetin to Ameliorate Cisplatin-induced Peripheral Neuropathy in Rats
por: Mahmoud, Heba A., et al.
Publicado: (2023)

Ancient founder mutation in RUBCN: a second unrelated family confirms Salih ataxia (SCAR15)
por: Seidahmed, Mohammed Z., et al.
Publicado: (2020)

Mitochondrial localization of SESN2
por: Kovaleva, Irina E., et al.
Publicado: (2020)

Tailoring Risperidone-Loaded Glycethosomal In Situ Gels Using Box–Behnken Design for Treatment of Schizophrenia-Induced Rats via Intranasal Route
por: Abdallah, Marwa H., et al.
Publicado: (2023)

Solanine Represses Gastric Cancer Growth by Mediating Autophagy Through AAMDC/MYC/ATF4/Sesn2 Signaling Pathway
por: Tang, Xiaolong, et al.
Publicado: (2023)

Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway
por: Ambrosio, S, et al.
Publicado: (2017)

Hypoxia-induced autophagy in triple negative breast cancer: association with prognostic variables, patients’ survival and response to neoadjuvant chemotherapy
por: El-Guindy, Dina M., et al.
Publicado: (2023)

SESN2 correlates with advantageous prognosis in hepatocellular carcinoma
por: Chen, Shaosen, et al.
Publicado: (2017)

Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression
por: Wang, Panxia, et al.
Publicado: (2020)

A 4-Gene Signature of CDKN1, FDXR, SESN1 and PCNA Radiation Biomarkers for Prediction of Patient Radiosensitivity
por: Howe, Orla, et al.
Publicado: (2021)

Regulation of endothelial ferroptosis by SESN1 in atherosclerosis and its related mechanism
por: Gao, Feng, et al.
Publicado: (2023)

SESN2 Could Be a Potential Marker for Diagnosis and Prognosis in Glioma
por: Xu, Lingdan, et al.
Publicado: (2023)

Association between the antioxidant properties of SESN proteins and anti-cancer therapies
por: Kozak, Joanna, et al.
Publicado: (2023)

Development and Optimization of Erythromycin Loaded Transethosomes Cinnamon Oil Based Emulgel for Antimicrobial Efficiency
por: Abdallah, Marwa H., et al.
Publicado: (2023)

FOXO3-mediated chemo-protection in high-stage neuroblastoma depends on wild-type TP53 and SESN3
por: Rupp, M, et al.
Publicado: (2017)

SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation
por: Kumar, Ashish, et al.
Publicado: (2018)

Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity
por: Abdallah, Marwa H., et al.
Publicado: (2022)

Regulatory Effects of Sestrin 3 (SESN3) in BCR-ABL Expressing Cells
por: Vakana, Eliza, et al.
Publicado: (2013)

SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing
por: Jing, Ying, et al.
Publicado: (2023)

Melatonin Ameliorates Ovarian Hyperstimulation Syndrome (OHSS) through SESN2 Regulated Antiapoptosis
por: Zheng, Min, et al.
Publicado: (2023)

SESN2 negatively regulates cell proliferation and casein synthesis by inhibition the amino acid-mediated mTORC1 pathway in cow mammary epithelial cells
por: Luo, Chaochao, et al.
Publicado: (2018)

SESN3 Inhibited SMAD3 to Relieve Its Suppression for MiR-124, Thus Regulating Pre-Adipocyte Adipogenesis
por: Lin, Weimin, et al.
Publicado: (2021)

Enhancement of the SESN2-SHP cascade by melatonin ameliorates hepatic gluconeogenesis by inhibiting the CRBN-BTG2-CREBH signaling pathway
por: An, Seungwon, et al.
Publicado: (2023)

Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress
por: Bodmer, Daniel, et al.
Publicado: (2017)

Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2
por: Liu, Xinmeng, et al.
Publicado: (2022)

SESN2 protects against denervated muscle atrophy through unfolded protein response and mitophagy
por: Yang, Xiaofan, et al.
Publicado: (2021)

SESN2 Knockdown Increases Betulinic Acid-Induced Radiosensitivity of Hypoxic Breast Cancer Cells
por: Güttler, Antje, et al.
Publicado: (2022)

Cardamonin exerts a protective effect against autophagy and apoptosis in the testicles of diabetic male rats through the expression of Nrf2 via p62-mediated Keap-1 degradation
por: Samir, Shereen M., et al.
Publicado: (2021)

MiR-23b Promotes Porcine Preadipocyte Differentiation via SESN3 and ACSL4
por: Li, Meng, et al.
Publicado: (2022)

The evolving role of long noncoding RNA HIF1A-AS2 in diabetic retinopathy: a cross-link axis between hypoxia, oxidative stress and angiogenesis via MAPK/VEGF-dependent pathway
por: Atef, Marwa Mohamed, et al.
Publicado: (2022)

Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway
por: Pan, Cunyao, et al.
Publicado: (2023)

Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration
por: Xu, Wen-Ning, et al.
Publicado: (2023)

Galectin-3 as a prognostic biomarker for diabetic nephropathy
por: Hodeib, Hossam, et al.
Publicado: (2019)

Arsenic trioxide-mediated suppression of miR-182-5p is associated with potent anti-oxidant effects through up-regulation of SESN2
por: Lin, Liang-Ting, et al.
Publicado: (2018)

2,3,4′,5-Tetrahydroxystilbene-2-O-β-D-glucoside ameliorates gentamicin-induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling
por: Wen, Yu-Hsuan, et al.
Publicado: (2022)

Usefulness of serum procalcitonin as a diagnostic biomarker of infection in children with chronic kidney disease
por: Fadel, Fatina I., et al.
Publicado: (2016)

OncomiR miR-182-5p Enhances Radiosensitivity by Inhibiting the Radiation-Induced Antioxidant Effect through SESN2 in Head and Neck Cancer
por: Lin, Min-Ying, et al.
Publicado: (2021)

Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis
por: Abd-Ellatif, Rania Nagi, et al.
Publicado: (2022)

Targeting on Nrf2/Sesn2 Signaling to Rescue Cardiac Dysfunction during High-Fat Diet-Induced Obesity
por: Krause-Hauch, Meredith, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_d9vhnm86e52sev2hlr2leeo291