Cargando…

Molecular Mechanics Simulations and Experimental Investigation of the Effect of Tadalafil on Various Inflammatory Pain Mediators

[Image: see text] Purpose: Tadalafil’s exact analgesic mechanism is still unclear. The current study aimed to elucidate this mechanism in an inflammatory pain model. Methods: Computer-assisted simulation docking experiments were carried out to assess the binding of tadalafil to different ligands. Th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Domiati, Souraya, Abd El Galil, Khaled, Ragab, Hanan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730770/ https://www.ncbi.nlm.nih.gov/pubmed/36506154 http://dx.doi.org/10.1021/acsomega.2c04761

Ejemplares similares

Structure-guided approach on the role of substitution on amide-linked bipyrazoles and its effect on their anti-inflammatory activity
por: Domiati, Souraya A., et al.
Publicado: (2022)

Investigation of chronic efficacy and safety profile of two potential anti-inflammatory bipyrazole-based compounds in experimental animals
por: Domiati, Souraya, et al.
Publicado: (2018)

Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity
por: Mehanna, Mohammed M, et al.
Publicado: (2020)

Knowledge, Attitude, and Practice of the Lebanese Community Toward COVID-19
por: Domiati, Souraya, et al.
Publicado: (2020)

Propranolol-Loaded Limonene-Based Microemulsion Thermo-Responsive Mucoadhesive Nasal Nanogel: Design, In Vitro Assessment, Ex Vivo Permeation, and Brain Biodistribution
por: Abla, Kawthar K., et al.
Publicado: (2023)

Anti-Inflammatory and Cardioprotective Effects of Tadalafil in Diabetic Mice
por: Varma, Amit, et al.
Publicado: (2012)

Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods
por: Školáková, Tereza, et al.
Publicado: (2019)

Tadalafil in the treatment of erectile dysfunction
por: Coward, Robert M, et al.
Publicado: (2008)

Myopathy with Concurrent Tadalafil and Simvastatin
por: Gargante, Maria Pia, et al.
Publicado: (2009)

The protective effect of single dose tadalafil in contrast-induced nephropathy: An experimental study
por: Özbek, Kerem, et al.
Publicado: (2015)

Upscaling the pharmacy profession: Knowledge and willingness of the Lebanese pharmacists to practice the administration of dermal fillers
por: Itani, Nayla, et al.
Publicado: (2022)

Efficacy of Continuous Dosing of Tadalafil Once Daily vs Tadalafil On Demand in Clinical Subgroups of Men With Erectile Dysfunction: A Descriptive Comparison Using the Integrated Tadalafil Databases
por: Brock, Gerald, et al.
Publicado: (2016)

Daily low dose of tadalafil improves pain and frequency in bladder pain syndrome/interstitial cystitis patients
por: Abreu-Mendes, Pedro, et al.
Publicado: (2022)

Central Serous Chorioretinopathy Associated with Tadalafil
por: Alsarhani, Abdulaziz, et al.
Publicado: (2022)

Enhanced Dissolution Rate of Tadalafil Nanoparticles Prepared by Sonoprecipitation Technique: Optimization and Physicochemical Investigation
por: Teymouri Rad, Rayehe, et al.
Publicado: (2017)

Impact of pretreatment with carnitine and tadalafil on contrast-induced nephropathy in CKD patients
por: Armaly, Zaher, et al.
Publicado: (2019)

Meta-Analysis of the Long-Term Efficacy and Tolerance of Tadalafil Daily Compared With Tadalafil On-Demand in Treating Men With Erectile Dysfunction
por: Zhou, Zhongbao, et al.
Publicado: (2019)

The Effect of Grapefruit Juice on the Pharmacokinetics of Tadalafil in Rats
por: Shen, Xiuwei, et al.
Publicado: (2020)

Effects of sildenafil and tadalafil on skin flap viability
por: Souza, Rafael A. C., et al.
Publicado: (2021)

Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe)
por: Hassel, Jessica C., et al.
Publicado: (2017)

Proniosomal Gel-Loaded Phosphodiesterase Inhibitors (Sildenafil, Vardenafil, and Tadalafil): Prospects for Topical Penile Therapy of Tadalafil for Treatment of Erectile Dysfunction
por: Mohamed, Soad A., et al.
Publicado: (2023)

Comparison of the efficacy of the early LI-SWT plus daily tadalafil with daily tadalafil only as penile rehabilitation for postprostatectomy erectile dysfunction
por: Jang, Se Won, et al.
Publicado: (2022)

Role of penile rehabilitation through daily intake of 5 mg tadalafil on erectile dysfunction after different presentations of penile fracture: a prospective case–control study
por: GamalEl Din, Sameh Fayek, et al.
Publicado: (2023)

Meta-Analysis of Efficacy and Safety of Tadalafil Plus Tamsulosin Compared with Tadalafil Alone in Treating Men with Benign Prostatic Hyperplasia and Erectile Dysfunction
por: Zhou, Zhongbao, et al.
Publicado: (2019)

Correction: Comparison of the efficacy of the early LI-SWT plus daily tadalafil with daily tadalafil only as penile rehabilitation for postprostatectomy erectile dysfunction
por: Jang, Se Won, et al.
Publicado: (2022)

Effect of tadalafil on blood flow, pain, and function in chronic cold Complex Regional Pain Syndrome: a randomized controlled trial
por: Groeneweg, George, et al.
Publicado: (2008)

Efficacy of tadalafil in Egyptian and Turkish men with erectile dysfunction
por: ŞAYLAN, M, et al.
Publicado: (2006)

Angioneurotic oedema with tadalafil: A rare case report
por: Raj, Rajnish, et al.
Publicado: (2006)

Effects of Systemic Tadalafil on Skin Flap Survival in Rats
por: Brewer, Michael B., et al.
Publicado: (2012)

Tadalafil in the treatment of erectile dysfunction; an overview of the clinical evidence
por: Frajese, Giovanni Vanni, et al.
Publicado: (2006)

Fixed drug eruption caused by tadalafil - Case report
por: Bjekic, Milan, et al.
Publicado: (2013)

Inhibition by tadalafil of contractility of isolated nonpregnant human myometrium
por: Sen, Sumalya, et al.
Publicado: (2016)

Penile Calciphylaxis treated with daily Tadalafil: Case report
por: Moya, Carlos Castro, et al.
Publicado: (2019)

The role of tadalafil in treated hypertensive patients with erectile dysfunction
por: Grossman, Ehud
Publicado: (2022)

Successful use of tadalafil in oligohydramnios associated with lupus pregnancy
por: Gupta, Kushagra, et al.
Publicado: (2023)

Design, Synthesis, Anticancer Evaluation and Molecular Modeling of Novel Estrogen Derivatives
por: Amr, Abd El-Galil E., et al.
Publicado: (2019)

Response to Letter to the Editor: Meta-Analysis of the Long-term Efficacy and Tolerance of Tadalafil Daily Compared With Tadalafil On-Demand in Treating Men With Erectile Dysfunction
por: Zhou, Zhongbao, et al.
Publicado: (2020)

Once-daily 5 mg tadalafil oral treatment for patients with chronic prostatitis/chronic pelvic pain syndrome
por: Benelli, Andrea, et al.
Publicado: (2018)

Is Tadalafil an Effective Treatment Option for Interstitial Cystitis/Painful Bladder Syndrome? A Report of a Challenging Case
por: Demirtaş, Abdullah, et al.
Publicado: (2021)

Antioxidant Behavior Affected by Polarity in the Olive Oil: Experimental and Molecular Simulation Investigations
por: Tang, Jie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_alr3fsn22gohcktv9lfge5q274