Targeting OCT2 with Duloxetine to Prevent Oxaliplatin-induced Peripheral Neurotoxicity

Oxaliplatin-induced peripheral neurotoxicity (OIPN) is a debilitating side effect that afflicts approximately 90% of patients that is initiated by OCT2-dependent uptake of oxaliplatin in dorsal root ganglion (DRG) neurons. The antidepressant drug duloxetine has been used to treat OIPN, although its...

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Detalles Bibliográficos
Autores principales: Nepal, Mahesh R., Taheri, Hanieh, Li, Yang, Talebi, Zahra, Uddin, Muhammad Erfan, Jin, Yan, DiGiacomo, Duncan F., Gibson, Alice A., Lustberg, Maryam B., Hu, Shuiying, Sparreboom, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730833/
https://www.ncbi.nlm.nih.gov/pubmed/36506732
http://dx.doi.org/10.1158/2767-9764.CRC-22-0172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730833/
https://www.ncbi.nlm.nih.gov/pubmed/36506732
http://dx.doi.org/10.1158/2767-9764.CRC-22-0172

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