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Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation

Recent advances in DNA sequencing technologies are revealing a large individual variability of the human genome. Our capacity to establish genotype-phenotype correlations in such large-scale is, however, limited. This task is particularly challenging due to the multifunctional nature of many protein...

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Detalles Bibliográficos
Autores principales: Pacheco-Garcia, Juan Luis, Cagiada, Matteo, Tienne-Matos, Kelly, Salido, Eduardo, Lindorff-Larsen, Kresten, L. Pey, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730889/
https://www.ncbi.nlm.nih.gov/pubmed/36504709
http://dx.doi.org/10.3389/fmolb.2022.1063620