Genomic Designs of rAAVs Contribute to Pathological Changes in the Livers and Spleens of Mice

Recombinant AAV (rAAV) gene therapy is being investigated as an effective therapy for several diseases including hemophilia B. Reports of liver tumor development in certain mouse models due to AAV treatment and genomic integration of the rAAV vector has raised concerns about the long-term safety and...

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Detalles Bibliográficos
Autores principales: Mulcrone, Patrick L., Zhang, Junping, Pride, P. Melanie, Lam, Anh K., Frabutt, Dylan A., Ball-Kell, Susan M., Xiao, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730939/
https://www.ncbi.nlm.nih.gov/pubmed/36507314
http://dx.doi.org/10.1155/2022/6807904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730939/
https://www.ncbi.nlm.nih.gov/pubmed/36507314
http://dx.doi.org/10.1155/2022/6807904

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