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Genomic Designs of rAAVs Contribute to Pathological Changes in the Livers and Spleens of Mice
Recombinant AAV (rAAV) gene therapy is being investigated as an effective therapy for several diseases including hemophilia B. Reports of liver tumor development in certain mouse models due to AAV treatment and genomic integration of the rAAV vector has raised concerns about the long-term safety and...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730939/ https://www.ncbi.nlm.nih.gov/pubmed/36507314 http://dx.doi.org/10.1155/2022/6807904 |