Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky with Kcc2 gene expression-enhancing treatments

Low intraneuronal chloride in spinal cord dorsal horn (SCDH) pain relay neurons is of critical relevance for physiological transmission of primary sensory afferents because low intraneuronal chloride dictates GABA-ergic and glycin-ergic neurotransmission to be inhibitory. If neuronal chloride rises...

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Detalles Bibliográficos
Autores principales: Yeo, Michele, Zhang, Qiaojuan, Ding, LeAnne, Shen, Xiangjun, Chen, Yong, Liedtke, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731339/
https://www.ncbi.nlm.nih.gov/pubmed/36504679
http://dx.doi.org/10.3389/fnmol.2022.911606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731339/
https://www.ncbi.nlm.nih.gov/pubmed/36504679
http://dx.doi.org/10.3389/fnmol.2022.911606

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