Drug resistance mechanisms create targetable proteostatic vulnerabilities in Her2+ breast cancers

Oncogenic kinase inhibitors show short-lived responses in the clinic due to high rate of acquired resistance. We previously showed that pharmacologically exploiting oncogene-induced proteotoxic stress can be a viable alternative to oncogene-targeted therapy. Here, we performed extensive analyses of...

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Detalles Bibliográficos
Autores principales: Singh, Navneet, Romick-Rosendale, Lindsey, Watanabe-Chailland, Miki, Privette Vinnedge, Lisa M., Komurov, Kakajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731458/
https://www.ncbi.nlm.nih.gov/pubmed/36480552
http://dx.doi.org/10.1371/journal.pone.0256788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731458/
https://www.ncbi.nlm.nih.gov/pubmed/36480552
http://dx.doi.org/10.1371/journal.pone.0256788

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