Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor

The insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) control metabolic homeostasis and cell growth and proliferation. The IR and IGF1R form similar disulfide bonds linked homodimers in the apo-state; however, their ligand binding properties and the structures in the active sta...

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Detalles Bibliográficos
Autores principales: Li, Jie, Wu, Jiayi, Hall, Catherine, Bai, Xiao-chen, Choi, Eunhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731570/
https://www.ncbi.nlm.nih.gov/pubmed/36413010
http://dx.doi.org/10.7554/eLife.81286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731570/
https://www.ncbi.nlm.nih.gov/pubmed/36413010
http://dx.doi.org/10.7554/eLife.81286

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