Cargando…

Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor

The insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) control metabolic homeostasis and cell growth and proliferation. The IR and IGF1R form similar disulfide bonds linked homodimers in the apo-state; however, their ligand binding properties and the structures in the active sta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jie, Wu, Jiayi, Hall, Catherine, Bai, Xiao-chen, Choi, Eunhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731570/ https://www.ncbi.nlm.nih.gov/pubmed/36413010 http://dx.doi.org/10.7554/eLife.81286

Ejemplares similares

Structural basis of the activation of type 1 insulin-like growth factor receptor
por: Li, Jie, et al.
Publicado: (2019)

The effect of insulin on equine lamellar basal epithelial cells mediated by the insulin-like growth factor-1 receptor
por: Baskerville, Courtnay L., et al.
Publicado: (2018)

Insulin receptor endocytosis in the pathophysiology of insulin resistance
por: Hall, Catherine, et al.
Publicado: (2020)

Activation of the insulin receptor by an insulin mimetic peptide
por: Park, Junhee, et al.
Publicado: (2022)

Spindle Checkpoint Regulators in Insulin Signaling
por: Choi, Eunhee, et al.
Publicado: (2018)

Autophagy downregulation contributes to insulin resistance mediated injury in insulin receptor knockout podocytes in vitro
por: Xu, Ying, et al.
Publicado: (2016)

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex
por: Uchikawa, Emiko, et al.
Publicado: (2019)

Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling
por: Sunters, Andrew, et al.
Publicado: (2010)

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis
por: Kearney, Alison L, et al.
Publicado: (2021)

Microenvironmental Determinants of Breast Cancer Metastasis: Focus on the Crucial Interplay Between Estrogen and Insulin/Insulin-Like Growth Factor Signaling
por: Vella, Veronica, et al.
Publicado: (2020)

How does obesity lead to insulin resistance?
por: Choi, Chan Hee J, et al.
Publicado: (2017)

Communication Between Autophagy and Insulin Action: At the Crux of Insulin Action-Insulin Resistance?
por: Frendo-Cumbo, Scott, et al.
Publicado: (2021)

Deciphering Brain Insulin Receptor and Insulin‐Like Growth Factor 1 Receptor Signalling
por: Kleinridders, A.
Publicado: (2016)

The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia
por: Ghafouri-Fard, Soudeh, et al.
Publicado: (2021)

How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor
por: Xu, Yibin, et al.
Publicado: (2022)

Specific sensory neurons and insulin-like peptides modulate food type-dependent oogenesis and fertilization in Caenorhabditis elegans
por: Mishra, Shashwat, et al.
Publicado: (2023)

LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation
por: Choi, Chan Hee J, et al.
Publicado: (2022)

Insulin, insulin-like growth factor–1, insulin receptor, and insulin-like growth factor–1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus
por: Penha, Alexandra Marcha, et al.
Publicado: (2011)

Insulin-like peptide 8 (Ilp8) regulates female fecundity in flies
por: Li, Haomiao, et al.
Publicado: (2023)

Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B
por: Giudice, Jimena, et al.
Publicado: (2013)

Altered Insulin Receptor Substrate 1 Phosphorylation in Blood Neuron-Derived Extracellular Vesicles From Patients With Parkinson’s Disease
por: Chou, Szu-Yi, et al.
Publicado: (2020)

Role of Insulin-like Growth Factor, Insulin-like Growth Factor Receptors, and Insulin-like Growth Factor-binding Proteins in Ovarian Cancer
por: Amutha, Periyasamy, et al.
Publicado: (2017)

The mannose 6‐phosphate/insulin‐like growth factor 2 receptor mediates plasminogen‐induced efferocytosis
por: Ohradanova‐Repic, Anna, et al.
Publicado: (2019)

Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance
por: Galal, Mariam Ahmed, et al.
Publicado: (2023)

Ligand-Mediated Endocytosis and Trafficking of the Insulin-Like Growth Factor Receptor I and Insulin Receptor Modulate Receptor Function
por: Morcavallo, Alaide, et al.
Publicado: (2014)

An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans
por: Martinez, Bryan A, et al.
Publicado: (2020)

Dnmt3a is an epigenetic mediator of adipose insulin resistance
por: You, Dongjoo, et al.
Publicado: (2017)

Combined and individual tumor-specific expression of insulin-like growth factor-I receptor, insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer: Implications for prognosis in different treatment groups
por: Björner, Sofie, et al.
Publicado: (2016)

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2
por: Kreutzberger, Alex J B, et al.
Publicado: (2020)

Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation
por: Tian, Dan, et al.
Publicado: (2016)

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine
por: Miller, Oliver H, et al.
Publicado: (2014)

The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults
por: Barry, William E, et al.
Publicado: (2016)

Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development
por: Wang, Kai, et al.
Publicado: (2019)

Protein kinase B/AKT phosphorylates hypoxia-inducible factor-3α1 in response to insulin, promoting cell growth and migration
por: Nguyen, Tran Vinh Hong, et al.
Publicado: (2023)

Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies
por: Farooq, Mariya, et al.
Publicado: (2021)

Insulin-like growth factor-2 regulates basal retinal insulin receptor activity
por: Zolov, Sergey N., et al.
Publicado: (2021)

Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles
por: Bueno, Ana B., et al.
Publicado: (2016)

A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding
por: Chrudinová, Martina, et al.
Publicado: (2018)

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle
por: Knudsen, Jonas R, et al.
Publicado: (2023)

Brain insulin receptors link stress and metabolism()
por: Woods, Stephen C., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_71vqufpl7dsebq00gsdhc4kii3