Long-range allostery mediates the regulation of plasminogen activator inhibitor-1 by cell adhesion factor vitronectin

The serpin plasminogen activator inhibitor 1 (PAI-1) spontaneously undergoes a massive structural change from a metastable and active conformation, with a solvent-accessible reactive center loop (RCL), to a stable, inactive, or latent conformation, with the RCL inserted into the central β-sheet. Phy...

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Detalles Bibliográficos
Autores principales: Kihn, Kyle, Marchiori, Elisa, Spagnolli, Giovanni, Boldrini, Alberto, Terruzzi, Luca, Lawrence, Daniel A., Gershenson, Anne, Faccioli, Pietro, Wintrode, Patrick L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731859/
https://www.ncbi.nlm.nih.gov/pubmed/36444882
http://dx.doi.org/10.1016/j.jbc.2022.102652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731859/
https://www.ncbi.nlm.nih.gov/pubmed/36444882
http://dx.doi.org/10.1016/j.jbc.2022.102652

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