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An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2
Elevated levels of cytokines IL-1β and IL-6 are associated with severe COVID-19. Investigating the underlying mechanisms, we find that while primary human airway epithelia (HAE) have functional inflammasomes and support SARS-CoV-2 replication, they are not the source of IL-1β released upon infection...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731922/ https://www.ncbi.nlm.nih.gov/pubmed/36563691 http://dx.doi.org/10.1016/j.chom.2022.12.005 |