An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2

Elevated levels of cytokines IL-1β and IL-6 are associated with severe COVID-19. Investigating the underlying mechanisms, we find that while primary human airway epithelia (HAE) have functional inflammasomes and support SARS-CoV-2 replication, they are not the source of IL-1β released upon infection...

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Detalles Bibliográficos
Autores principales: Barnett, Katherine C., Xie, Yuying, Asakura, Takanori, Song, Dingka, Liang, Kaixin, Taft-Benz, Sharon A., Guo, Haitao, Yang, Shuangshuang, Okuda, Kenichi, Gilmore, Rodney C., Loome, Jennifer F., Oguin III, Thomas H., Sempowski, Gregory D., Randell, Scott H., Heise, Mark T., Lei, Yu Leo, Boucher, Richard C., Ting, Jenny P.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731922/
https://www.ncbi.nlm.nih.gov/pubmed/36563691
http://dx.doi.org/10.1016/j.chom.2022.12.005

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