Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia

Solid tumors often contain regions with very low oxygen concentrations or hypoxia resulting from altered metabolism, uncontrolled proliferation, and abnormal tumor blood vessels. Hypoxia leads to resistance to both radio- and chemotherapy and a predisposition to tumor metastases. Under hypoxia, sequ...

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Detalles Bibliográficos
Autores principales: Siswanto, Ferbian Milas, Mitsuoka, Yumi, Nakamura, Misato, Oguro, Ami, Imaoka, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731985/
https://www.ncbi.nlm.nih.gov/pubmed/36481701
http://dx.doi.org/10.1038/s41598-022-25784-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731985/
https://www.ncbi.nlm.nih.gov/pubmed/36481701
http://dx.doi.org/10.1038/s41598-022-25784-0

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