Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation

How the carbohydrate binding protein galectin-3 might act as a diabetogenic and tumorogenic factor remains to be investigated. Here we report that intracellular galectin-3 interacts with Rag GTPases and Ragulator on lysosomes. We show that galectin-3 senses lipopolysaccharide (LPS) to facilitate the...

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Detalles Bibliográficos
Autores principales: Chen, Xing, Yu, Chunyu, Liu, Xinhua, Liu, Beibei, Wu, Xiaodi, Wu, Jiajing, Yan, Dong, Han, Lulu, Tang, Zifan, Yuan, Xinyi, Wang, Jianqiu, Wang, Yue, Liu, Shumeng, Shan, Lin, Shang, Yongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732310/
https://www.ncbi.nlm.nih.gov/pubmed/36481721
http://dx.doi.org/10.1038/s41467-022-35334-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732310/
https://www.ncbi.nlm.nih.gov/pubmed/36481721
http://dx.doi.org/10.1038/s41467-022-35334-x

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