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Solid pancreatic masses in children: A review of current evidence and clinical challenges

Pancreatic tumors in children are infrequently encountered in clinical practice. Their non-specific clinical presentation and overlapping imaging characteristics often make an accurate preoperative diagnosis difficult. Tumors are categorized as epithelial or non-epithelial, with epithelial tumors fu...

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Autores principales: Patterson, Kelli N., Trout, Andrew T., Shenoy, Archana, Abu-El-Haija, Maisam, Nathan, Jaimie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732489/
https://www.ncbi.nlm.nih.gov/pubmed/36507125
http://dx.doi.org/10.3389/fped.2022.966943
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author Patterson, Kelli N.
Trout, Andrew T.
Shenoy, Archana
Abu-El-Haija, Maisam
Nathan, Jaimie D.
author_facet Patterson, Kelli N.
Trout, Andrew T.
Shenoy, Archana
Abu-El-Haija, Maisam
Nathan, Jaimie D.
author_sort Patterson, Kelli N.
collection PubMed
description Pancreatic tumors in children are infrequently encountered in clinical practice. Their non-specific clinical presentation and overlapping imaging characteristics often make an accurate preoperative diagnosis difficult. Tumors are categorized as epithelial or non-epithelial, with epithelial tumors further classified as tumors of the exocrine or endocrine pancreas. Although both are tumors of the exocrine pancreas, solid pseudopapillary neoplasm is the most prevalent solid pancreatic tumor in children, while pancreatoblastoma is the most common malignant tumor. Insulinoma is the most common pediatric pancreatic tumor of the endocrine pancreas. Malignant tumors require a complete, often radical, surgical resection. However, pancreatic parenchyma-sparing surgical procedures are utilized for benign tumors and low-grade malignancy to preserve gland function. This review will discuss the epidemiology, pathophysiology, clinical and diagnostic characteristics, and management options associated with both common and rare solid pancreatic masses in children. We will also discuss current challenges encountered in their evaluation and treatment.
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spelling pubmed-97324892022-12-10 Solid pancreatic masses in children: A review of current evidence and clinical challenges Patterson, Kelli N. Trout, Andrew T. Shenoy, Archana Abu-El-Haija, Maisam Nathan, Jaimie D. Front Pediatr Pediatrics Pancreatic tumors in children are infrequently encountered in clinical practice. Their non-specific clinical presentation and overlapping imaging characteristics often make an accurate preoperative diagnosis difficult. Tumors are categorized as epithelial or non-epithelial, with epithelial tumors further classified as tumors of the exocrine or endocrine pancreas. Although both are tumors of the exocrine pancreas, solid pseudopapillary neoplasm is the most prevalent solid pancreatic tumor in children, while pancreatoblastoma is the most common malignant tumor. Insulinoma is the most common pediatric pancreatic tumor of the endocrine pancreas. Malignant tumors require a complete, often radical, surgical resection. However, pancreatic parenchyma-sparing surgical procedures are utilized for benign tumors and low-grade malignancy to preserve gland function. This review will discuss the epidemiology, pathophysiology, clinical and diagnostic characteristics, and management options associated with both common and rare solid pancreatic masses in children. We will also discuss current challenges encountered in their evaluation and treatment. Frontiers Media S.A. 2022-11-25 /pmc/articles/PMC9732489/ /pubmed/36507125 http://dx.doi.org/10.3389/fped.2022.966943 Text en © 2022 Patterson, Trout, Shenoy, Abu-El-Haija and Nathan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Patterson, Kelli N.
Trout, Andrew T.
Shenoy, Archana
Abu-El-Haija, Maisam
Nathan, Jaimie D.
Solid pancreatic masses in children: A review of current evidence and clinical challenges
title Solid pancreatic masses in children: A review of current evidence and clinical challenges
title_full Solid pancreatic masses in children: A review of current evidence and clinical challenges
title_fullStr Solid pancreatic masses in children: A review of current evidence and clinical challenges
title_full_unstemmed Solid pancreatic masses in children: A review of current evidence and clinical challenges
title_short Solid pancreatic masses in children: A review of current evidence and clinical challenges
title_sort solid pancreatic masses in children: a review of current evidence and clinical challenges
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732489/
https://www.ncbi.nlm.nih.gov/pubmed/36507125
http://dx.doi.org/10.3389/fped.2022.966943
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