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Solid pancreatic masses in children: A review of current evidence and clinical challenges
Pancreatic tumors in children are infrequently encountered in clinical practice. Their non-specific clinical presentation and overlapping imaging characteristics often make an accurate preoperative diagnosis difficult. Tumors are categorized as epithelial or non-epithelial, with epithelial tumors fu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732489/ https://www.ncbi.nlm.nih.gov/pubmed/36507125 http://dx.doi.org/10.3389/fped.2022.966943 |
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author | Patterson, Kelli N. Trout, Andrew T. Shenoy, Archana Abu-El-Haija, Maisam Nathan, Jaimie D. |
author_facet | Patterson, Kelli N. Trout, Andrew T. Shenoy, Archana Abu-El-Haija, Maisam Nathan, Jaimie D. |
author_sort | Patterson, Kelli N. |
collection | PubMed |
description | Pancreatic tumors in children are infrequently encountered in clinical practice. Their non-specific clinical presentation and overlapping imaging characteristics often make an accurate preoperative diagnosis difficult. Tumors are categorized as epithelial or non-epithelial, with epithelial tumors further classified as tumors of the exocrine or endocrine pancreas. Although both are tumors of the exocrine pancreas, solid pseudopapillary neoplasm is the most prevalent solid pancreatic tumor in children, while pancreatoblastoma is the most common malignant tumor. Insulinoma is the most common pediatric pancreatic tumor of the endocrine pancreas. Malignant tumors require a complete, often radical, surgical resection. However, pancreatic parenchyma-sparing surgical procedures are utilized for benign tumors and low-grade malignancy to preserve gland function. This review will discuss the epidemiology, pathophysiology, clinical and diagnostic characteristics, and management options associated with both common and rare solid pancreatic masses in children. We will also discuss current challenges encountered in their evaluation and treatment. |
format | Online Article Text |
id | pubmed-9732489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97324892022-12-10 Solid pancreatic masses in children: A review of current evidence and clinical challenges Patterson, Kelli N. Trout, Andrew T. Shenoy, Archana Abu-El-Haija, Maisam Nathan, Jaimie D. Front Pediatr Pediatrics Pancreatic tumors in children are infrequently encountered in clinical practice. Their non-specific clinical presentation and overlapping imaging characteristics often make an accurate preoperative diagnosis difficult. Tumors are categorized as epithelial or non-epithelial, with epithelial tumors further classified as tumors of the exocrine or endocrine pancreas. Although both are tumors of the exocrine pancreas, solid pseudopapillary neoplasm is the most prevalent solid pancreatic tumor in children, while pancreatoblastoma is the most common malignant tumor. Insulinoma is the most common pediatric pancreatic tumor of the endocrine pancreas. Malignant tumors require a complete, often radical, surgical resection. However, pancreatic parenchyma-sparing surgical procedures are utilized for benign tumors and low-grade malignancy to preserve gland function. This review will discuss the epidemiology, pathophysiology, clinical and diagnostic characteristics, and management options associated with both common and rare solid pancreatic masses in children. We will also discuss current challenges encountered in their evaluation and treatment. Frontiers Media S.A. 2022-11-25 /pmc/articles/PMC9732489/ /pubmed/36507125 http://dx.doi.org/10.3389/fped.2022.966943 Text en © 2022 Patterson, Trout, Shenoy, Abu-El-Haija and Nathan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Patterson, Kelli N. Trout, Andrew T. Shenoy, Archana Abu-El-Haija, Maisam Nathan, Jaimie D. Solid pancreatic masses in children: A review of current evidence and clinical challenges |
title | Solid pancreatic masses in children: A review of current evidence and clinical challenges |
title_full | Solid pancreatic masses in children: A review of current evidence and clinical challenges |
title_fullStr | Solid pancreatic masses in children: A review of current evidence and clinical challenges |
title_full_unstemmed | Solid pancreatic masses in children: A review of current evidence and clinical challenges |
title_short | Solid pancreatic masses in children: A review of current evidence and clinical challenges |
title_sort | solid pancreatic masses in children: a review of current evidence and clinical challenges |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732489/ https://www.ncbi.nlm.nih.gov/pubmed/36507125 http://dx.doi.org/10.3389/fped.2022.966943 |
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