Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors

A series of pyrazolyl-s-triazine compounds with an indole motif was designed, synthesized, and evaluated for anticancer activity targeting dual EGFR and CDK-2 inhibitors. The compounds were tested for cytotoxicity using the MTT assay. Compounds 3h, 3i, and 3j showed promising cytotoxic activity agai...

Descripción completa

Detalles Bibliográficos
Autores principales: Shawish, Ihab, Nafie, Mohamed S., Barakat, Assem, Aldalbahi, Ali, Al-Rasheed, Hessa H., Ali, M., Alshaer, Walhan, Al Zoubi, Mazhar, Al Ayoubi, Samha, De la Torre, Beatriz G., Albericio, Fernando, El-Faham, Ayman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732672/
https://www.ncbi.nlm.nih.gov/pubmed/36505739
http://dx.doi.org/10.3389/fchem.2022.1078163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732672/
https://www.ncbi.nlm.nih.gov/pubmed/36505739
http://dx.doi.org/10.3389/fchem.2022.1078163

Ejemplares similares