Cargando…

Role of Hydrophobicity at the N-Terminal Region of Aβ42 in Secondary Nucleation

[Image: see text] The self-assembly of the amyloid β 42 (Aβ42) peptide is linked to Alzheimer’s disease, and oligomeric intermediates are linked to neuronal cell death during the pathology of the disease. These oligomers are produced prolifically during secondary nucleation, by which the aggregation...

Descripción completa

Detalles Bibliográficos
Autores principales: Thacker, Dev, Willas, Amanda, Dear, Alexander J., Linse, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732875/
https://www.ncbi.nlm.nih.gov/pubmed/36411082
http://dx.doi.org/10.1021/acschemneuro.2c00504