TRF1 uses a noncanonical function of TFIIH to promote telomere replication

Telomeric DNA challenges the replisome and requires TRF1 for efficient duplication. TRF1 recruits the BLM helicase, but BLM loss does not explain the extensive telomere fragility, ATR signaling, and sister telomere associations (STAs) induced by TRF1 deletion. Here, we document that Helix2 of the TR...

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Detalles Bibliográficos
Autores principales: Yang, Zhe, Sharma, Keshav, de Lange, Titia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732906/
https://www.ncbi.nlm.nih.gov/pubmed/36229075
http://dx.doi.org/10.1101/gad.349975.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732906/
https://www.ncbi.nlm.nih.gov/pubmed/36229075
http://dx.doi.org/10.1101/gad.349975.122

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