A synthetic KLHL20 ligand to validate CUL3(KLHL20) as a potent E3 ligase for targeted protein degradation

Targeted protein degradation (TPD) has risen as a promising therapeutic modality. Leveraging the catalytic nature of the ubiquitin–proteasome enzymatic machinery, TPD exhibits higher potency to eliminate disease-causing target proteins such as oncogenic transcription factors that may otherwise be di...

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Detalles Bibliográficos
Autores principales: Farrell, Brian M., Gerth, Fabian, Yang, Cheng-Hao R., Yeh, Johannes T.-H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Resource/Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732910/
https://www.ncbi.nlm.nih.gov/pubmed/36328355
http://dx.doi.org/10.1101/gad.349717.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732910/
https://www.ncbi.nlm.nih.gov/pubmed/36328355
http://dx.doi.org/10.1101/gad.349717.122

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