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A synthetic KLHL20 ligand to validate CUL3(KLHL20) as a potent E3 ligase for targeted protein degradation
Targeted protein degradation (TPD) has risen as a promising therapeutic modality. Leveraging the catalytic nature of the ubiquitin–proteasome enzymatic machinery, TPD exhibits higher potency to eliminate disease-causing target proteins such as oncogenic transcription factors that may otherwise be di...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732910/ https://www.ncbi.nlm.nih.gov/pubmed/36328355 http://dx.doi.org/10.1101/gad.349717.122 |