EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax

BACKGROUND: Acute myeloid leukemia (AML) is an aggressive hematological cancer resulting from uncontrolled proliferation of differentiation-blocked myeloid cells. Seventy percent of AML patients are currently not cured with available treatments, highlighting the need of novel therapeutic strategies....

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Detalles Bibliográficos
Autores principales: Fooks, Katie, Galicia-Vazquez, Gabriela, Gife, Victor, Schcolnik-Cabrera, Alejandro, Nouhi, Zaynab, Poon, William W. L., Luo, Vincent, Rys, Ryan N., Aloyz, Raquel, Orthwein, Alexandre, Johnson, Nathalie A., Hulea, Laura, Mercier, Francois E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733142/
https://www.ncbi.nlm.nih.gov/pubmed/36482393
http://dx.doi.org/10.1186/s13046-022-02542-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733142/
https://www.ncbi.nlm.nih.gov/pubmed/36482393
http://dx.doi.org/10.1186/s13046-022-02542-8

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