pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity

3-Chymotrypsin-like protease (3CLpro) is a promising drug target for coronavirus disease 2019 and related coronavirus diseases because of the essential role of this protease in processing viral polyproteins after infection. Understanding the detailed catalytic mechanism of 3CLpro is essential for de...

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Detalles Bibliográficos
Autores principales: Al Adem, Kenana, Ferreira, Juliana C., Fadl, Samar, Rabeh, Wael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733303/
https://www.ncbi.nlm.nih.gov/pubmed/36509143
http://dx.doi.org/10.1016/j.jbc.2022.102790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733303/
https://www.ncbi.nlm.nih.gov/pubmed/36509143
http://dx.doi.org/10.1016/j.jbc.2022.102790

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