Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy

BACKGROUND: Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of the amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) disease spectrum, causing both nuclear loss-of-function and cytoplasmic toxic gain-of-function phenotypes. While TDP...

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Detalles Bibliográficos
Autores principales: Khalil, Bilal, Chhangani, Deepak, Wren, Melissa C., Smith, Courtney L., Lee, Jannifer H., Li, Xingli, Puttinger, Christian, Tsai, Chih-Wei, Fortin, Gael, Morderer, Dmytro, Gao, Junli, Liu, Feilin, Lim, Chun Kim, Chen, Jingjiao, Chou, Ching-Chieh, Croft, Cara L., Gleixner, Amanda M., Donnelly, Christopher J., Golde, Todd E., Petrucelli, Leonard, Oskarsson, Björn, Dickson, Dennis W., Zhang, Ke, Shorter, James, Yoshimura, Shige H., Barmada, Sami J., Rincon-Limas, Diego E., Rossoll, Wilfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733332/
https://www.ncbi.nlm.nih.gov/pubmed/36482422
http://dx.doi.org/10.1186/s13024-022-00585-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733332/
https://www.ncbi.nlm.nih.gov/pubmed/36482422
http://dx.doi.org/10.1186/s13024-022-00585-1

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