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A Poisson reduced-rank regression model for association mapping in sequencing data

BACKGROUND: Single-cell RNA-sequencing (scRNA-seq) technologies allow for the study of gene expression in individual cells. Often, it is of interest to understand how transcriptional activity is associated with cell-specific covariates, such as cell type, genotype, or measures of cell health. Tradit...

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Detalles Bibliográficos
Autores principales: Fitzgerald, Tiana, Jones, Andrew, Engelhardt, Barbara E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733401/
https://www.ncbi.nlm.nih.gov/pubmed/36482321
http://dx.doi.org/10.1186/s12859-022-05054-6