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Rap1b-loss increases neutrophil lactate dehydrogenase activity to enhance neutrophil migration and acute inflammation in vivo

INTRODUCTION: Neutrophils are critical for host immune defense; yet, aberrant neutrophil tissue infiltration triggers tissue damage. Neutrophils are heterogeneous functionally, and adopt ‘normal’ or ‘pathogenic’ effector function responses. Understanding neutrophil heterogeneity could provide specif...

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Detalles Bibliográficos
Autores principales: Chowdhury, Chanchal Sur, Wareham, Elizabeth, Xu, Juying, Kumar, Sachin, Kofron, Matthew, Lakshmikanthan, Sribalaji, Chrzanowska, Magdalena, Filippi, Marie-Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733537/
https://www.ncbi.nlm.nih.gov/pubmed/36505495
http://dx.doi.org/10.3389/fimmu.2022.1061544