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Combinatorial biosynthesis yields novel hybrid argimycin P alkaloids with diverse scaffolds in Streptomyces argillaceus

Coelimycin P1 and argimycins P are two types of polyketide alkaloids produced by Streptomyces coelicolor and Streptomyces argillaceus, respectively. Their biosynthesis pathways share some early steps that render very similar aminated polyketide chains, diverging the pathways afterwards. By expressin...

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Detalles Bibliográficos
Autores principales: Ye, Suhui, Ballin, Giovanni, Pérez‐Victoria, Ignacio, Braña, Alfredo F., Martín, Jesús, Reyes, Fernando, Salas, José A., Méndez, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733639/
https://www.ncbi.nlm.nih.gov/pubmed/36346129
http://dx.doi.org/10.1111/1751-7915.14167