Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia

Dysregulation of kinase signaling pathways favors tumor cell survival and therapy resistance in cancer. Here, we reveal a posttranslational regulation of kinase signaling and nuclear receptor activity via deubiquitination in T cell acute lymphoblastic leukemia (T-ALL). We observed that the ubiquitin...

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Detalles Bibliográficos
Autores principales: Jin, Qi, Gutierrez Diaz, Blanca, Pieters, Tim, Zhou, Yalu, Narang, Sonali, Fijalkwoski, Igor, Borin, Cristina, Van Laere, Jolien, Payton, Monique, Cho, Byoung-Kyu, Han, Cuijuan, Sun, Limin, Serafin, Valentina, Yacu, George, Von Loocke, Wouter, Basso, Giuseppe, Veltri, Giulia, Dreveny, Ingrid, Ben-Sahra, Issam, Goo, Young Ah, Safgren, Stephanie L., Tsai, Yi-Chien, Bornhauser, Beat, Suraneni, Praveen Kumar, Gaspar-Maia, Alexandre, Kandela, Irawati, Van Vlierberghe, Pieter, Crispino, John D., Tsirigos, Aristotelis, Ntziachristos, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733937/
https://www.ncbi.nlm.nih.gov/pubmed/36490346
http://dx.doi.org/10.1126/sciadv.abq8437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733937/
https://www.ncbi.nlm.nih.gov/pubmed/36490346
http://dx.doi.org/10.1126/sciadv.abq8437

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