MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer’s Disease

Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder, which is characterized by cognitive deficit due to synaptic loss and neuronal death. Extracellular amyloid β plaques are one of the pathological hallmarks of AD. The autophagic lysosomal pathway is the essential mechanism to maint...

Descripción completa

Detalles Bibliográficos
Autores principales: Chun, Yoon Sun, Kim, Mi-Yeon, Lee, Sun-Young, Kim, Mi Jeong, Hong, Tae-Joon, Jeon, Jae Kyong, Ganbat, Dulguun, Kim, Hyoung Tae, Kim, Sang Seong, Kam, Tae-In, Han, Sungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734062/
https://www.ncbi.nlm.nih.gov/pubmed/35948663
http://dx.doi.org/10.1038/s41380-022-01713-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734062/
https://www.ncbi.nlm.nih.gov/pubmed/35948663
http://dx.doi.org/10.1038/s41380-022-01713-5

Ejemplares similares