Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling

Depression and anxiety are major global health burdens. Although SSRIs targeting the serotonergic system are prescribed over 200 million times annually, they have variable therapeutic efficacy and side effects, and mechanisms of action remain incompletely understood. Here, we comprehensively charact...

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Detalles Bibliográficos
Autores principales: Rayan, Nirmala Arul, Kumar, Vibhor, Aow, Jonathan, Rastegar, Naghmeh, Lim, Michelle Gek Liang, O’Toole, Nicholas, Aliwarga, Edita, Arcego, Danusa Mar, Yeo, Hui Ting Grace, Wong, Jen Yi, Lee, May Yin, Schmidt, Florian, Haja, Hajira Shreen, Tam, Wai Leong, Zhang, Tie-Yuan, Diorio, Josie, Anacker, Christoph, Hen, Rene, Parent, Carine, Meaney, Michael J, Prabhakar, Shyam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734063/
https://www.ncbi.nlm.nih.gov/pubmed/36056172
http://dx.doi.org/10.1038/s41380-022-01725-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734063/
https://www.ncbi.nlm.nih.gov/pubmed/36056172
http://dx.doi.org/10.1038/s41380-022-01725-1

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