Regulating voltage-gated ion channels with nanobodies

In this work, Morgenstern and colleagues describe an approach involving functionalized nanobodies which decrease the activity of voltage-gated Ca(2+) channels associated with β(1) subunits and promote their removal from the surface membrane of neurons and muscle.

Detalles Bibliográficos
Autores principales: Manning, Declan, Santana, L. Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734093/
https://www.ncbi.nlm.nih.gov/pubmed/36494383
http://dx.doi.org/10.1038/s41467-022-35027-5
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author Manning, Declan
Santana, L. Fernando
author_facet Manning, Declan
Santana, L. Fernando
author_sort Manning, Declan
collection PubMed
description In this work, Morgenstern and colleagues describe an approach involving functionalized nanobodies which decrease the activity of voltage-gated Ca(2+) channels associated with β(1) subunits and promote their removal from the surface membrane of neurons and muscle.
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spelling pubmed-97340932022-12-11 Regulating voltage-gated ion channels with nanobodies Manning, Declan Santana, L. Fernando Nat Commun Comment In this work, Morgenstern and colleagues describe an approach involving functionalized nanobodies which decrease the activity of voltage-gated Ca(2+) channels associated with β(1) subunits and promote their removal from the surface membrane of neurons and muscle. Nature Publishing Group UK 2022-12-09 /pmc/articles/PMC9734093/ /pubmed/36494383 http://dx.doi.org/10.1038/s41467-022-35027-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Manning, Declan
Santana, L. Fernando
Regulating voltage-gated ion channels with nanobodies
title Regulating voltage-gated ion channels with nanobodies
title_full Regulating voltage-gated ion channels with nanobodies
title_fullStr Regulating voltage-gated ion channels with nanobodies
title_full_unstemmed Regulating voltage-gated ion channels with nanobodies
title_short Regulating voltage-gated ion channels with nanobodies
title_sort regulating voltage-gated ion channels with nanobodies
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734093/
https://www.ncbi.nlm.nih.gov/pubmed/36494383
http://dx.doi.org/10.1038/s41467-022-35027-5
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