Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation

ATP phosphoribosyltransferase catalyses the first step of histidine biosynthesis and is controlled via a complex allosteric mechanism where the regulatory protein HisZ enhances catalysis by the catalytic protein HisG(S) while mediating allosteric inhibition by histidine. Activation by HisZ was propo...

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Detalles Bibliográficos
Autores principales: Fisher, Gemma, Corbella, Marina, Alphey, Magnus S., Nicholson, John, Read, Benjamin J., Kamerlin, Shina C. L., da Silva, Rafael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734150/
https://www.ncbi.nlm.nih.gov/pubmed/36494361
http://dx.doi.org/10.1038/s41467-022-34960-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734150/
https://www.ncbi.nlm.nih.gov/pubmed/36494361
http://dx.doi.org/10.1038/s41467-022-34960-9

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