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Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation
ATP phosphoribosyltransferase catalyses the first step of histidine biosynthesis and is controlled via a complex allosteric mechanism where the regulatory protein HisZ enhances catalysis by the catalytic protein HisG(S) while mediating allosteric inhibition by histidine. Activation by HisZ was propo...
Autores principales: | Fisher, Gemma, Corbella, Marina, Alphey, Magnus S., Nicholson, John, Read, Benjamin J., Kamerlin, Shina C. L., da Silva, Rafael G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734150/ https://www.ncbi.nlm.nih.gov/pubmed/36494361 http://dx.doi.org/10.1038/s41467-022-34960-9 |
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