Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration

Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the accumulation of protein, which can be toxic to cells and tissue. In a subset of frontotemporal lobar degeneration with tau pathology (FTLD-tau) cases, pathogenic mutations i...

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Detalles Bibliográficos
Autores principales: Mahali, Sidhartha, Martinez, Rita, King, Melvin, Verbeck, Anthony, Harari, Oscar, Benitez, Bruno A., Horie, Kanta, Sato, Chihiro, Temple, Sally, Karch, Celeste M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734180/
https://www.ncbi.nlm.nih.gov/pubmed/36494352
http://dx.doi.org/10.1038/s41398-022-02274-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734180/
https://www.ncbi.nlm.nih.gov/pubmed/36494352
http://dx.doi.org/10.1038/s41398-022-02274-5

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