Cargando…
Impaired CD4(+) T cell recognition of SARS-CoV-2 variants of concern
We isolated CD4(+) T cell clones from healthcare workers infected with SARS-CoV-2 during the first COVID-19 wave and identified 21 epitopes across three viral proteins: spike, membrane and nucleoprotein. Focusing on spike protein, for seven of ten epitopes mutated in variants of concern, we found th...
| Formato: | Online Artículo Texto |
|---|---|
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734360/ https://www.ncbi.nlm.nih.gov/pubmed/36474117 http://dx.doi.org/10.1038/s41590-022-01353-5 |
| _version_ | 1784846570589519872 |
|---|---|
| collection | PubMed |
| description | We isolated CD4(+) T cell clones from healthcare workers infected with SARS-CoV-2 during the first COVID-19 wave and identified 21 epitopes across three viral proteins: spike, membrane and nucleoprotein. Focusing on spike protein, for seven of ten epitopes mutated in variants of concern, we found that T cell recognition was impaired. |
| format | Online Article Text |
| id | pubmed-9734360 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group US |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-97343602022-12-12 Impaired CD4(+) T cell recognition of SARS-CoV-2 variants of concern Nat Immunol Research Briefing We isolated CD4(+) T cell clones from healthcare workers infected with SARS-CoV-2 during the first COVID-19 wave and identified 21 epitopes across three viral proteins: spike, membrane and nucleoprotein. Focusing on spike protein, for seven of ten epitopes mutated in variants of concern, we found that T cell recognition was impaired. Nature Publishing Group US 2022-12-06 2022 /pmc/articles/PMC9734360/ /pubmed/36474117 http://dx.doi.org/10.1038/s41590-022-01353-5 Text en © Springer Nature America, Inc. 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Research Briefing Impaired CD4(+) T cell recognition of SARS-CoV-2 variants of concern |
| title | Impaired CD4(+) T cell recognition of SARS-CoV-2 variants of concern |
| title_full | Impaired CD4(+) T cell recognition of SARS-CoV-2 variants of concern |
| title_fullStr | Impaired CD4(+) T cell recognition of SARS-CoV-2 variants of concern |
| title_full_unstemmed | Impaired CD4(+) T cell recognition of SARS-CoV-2 variants of concern |
| title_short | Impaired CD4(+) T cell recognition of SARS-CoV-2 variants of concern |
| title_sort | impaired cd4(+) t cell recognition of sars-cov-2 variants of concern |
| topic | Research Briefing |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734360/ https://www.ncbi.nlm.nih.gov/pubmed/36474117 http://dx.doi.org/10.1038/s41590-022-01353-5 |