Molecular basis of C9orf72 poly-PR interference with the β-karyopherin family of nuclear transport receptors

Nucleocytoplasmic transport (NCT) is affected in several neurodegenerative diseases including C9orf72-ALS. It has recently been found that arginine-containing dipeptide repeat proteins (R-DPRs), translated from C9orf72 repeat expansions, directly bind to several importins. To gain insight into how t...

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Detalles Bibliográficos
Autores principales: Jafarinia, Hamidreza, Van der Giessen, Erik, Onck, Patrick R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734553/
https://www.ncbi.nlm.nih.gov/pubmed/36494425
http://dx.doi.org/10.1038/s41598-022-25732-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734553/
https://www.ncbi.nlm.nih.gov/pubmed/36494425
http://dx.doi.org/10.1038/s41598-022-25732-y

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