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Molecular basis of C9orf72 poly-PR interference with the β-karyopherin family of nuclear transport receptors
Nucleocytoplasmic transport (NCT) is affected in several neurodegenerative diseases including C9orf72-ALS. It has recently been found that arginine-containing dipeptide repeat proteins (R-DPRs), translated from C9orf72 repeat expansions, directly bind to several importins. To gain insight into how t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734553/ https://www.ncbi.nlm.nih.gov/pubmed/36494425 http://dx.doi.org/10.1038/s41598-022-25732-y |