Is There a Role for Immunoregulatory and Antiviral Oligonucleotides Acting in the Extracellular Space? A Review and Hypothesis

Here, we link approved and emerging nucleic acid-based therapies with the expanding universe of small non-coding RNAs (sncRNAs) and the innate immune responses that sense oligonucleotides taken up into endosomes. The Toll-like receptors (TLRs) 3, 7, 8, and 9 are located in endosomes and can detect n...

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Detalles Bibliográficos
Autores principales: Dondalska, Aleksandra, Axberg Pålsson, Sandra, Spetz, Anna-Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735517/
https://www.ncbi.nlm.nih.gov/pubmed/36498932
http://dx.doi.org/10.3390/ijms232314593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735517/
https://www.ncbi.nlm.nih.gov/pubmed/36498932
http://dx.doi.org/10.3390/ijms232314593

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