Shikonin as a WT1 Inhibitor Promotes Promyeloid Leukemia Cell Differentiation

This study aims to observe the differentiating effect of shikonin on Wilms’ tumor 1 (WT1)-positive HL-60 cells and investigate the fate of the differentiated leukemia cells. WT1 overexpression unaffected cell viability but promoted resistance to H(2)O(2)-induced DNA injury and cell apoptosis. The bi...

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Detalles Bibliográficos
Autores principales: Guo, Zhenzhen, Sun, Luyao, Xia, Haojie, Tian, Shibin, Liu, Mengyue, Hou, Jiejie, Li, Jiahuan, Lin, Haihong, Du, Gangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735585/
https://www.ncbi.nlm.nih.gov/pubmed/36500358
http://dx.doi.org/10.3390/molecules27238264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735585/
https://www.ncbi.nlm.nih.gov/pubmed/36500358
http://dx.doi.org/10.3390/molecules27238264

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