Acid-Switchable Synthesis of Trifluoromethylated Triazoles and Isoxazoles via Reaction of CF(3)-Ynones with NaN(3): DFT Study of the Reaction Mechanism

A detailed study of the reaction of CF(3)-ynones with NaN(3) was performed. It was found that the reaction permits the selective synthesis of either 4-trifluoroacetyltriazoles or 5-CF(3)-isoxazoles. The chemoselectivity of the reaction was switchable via acid catalysis. The reaction of CF(3)-ynones...

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Detalles Bibliográficos
Autores principales: Muzalevskiy, Vasiliy M., Sizova, Zoia A., Nechaev, Mikhail S., Nenajdenko, Valentine G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735682/
https://www.ncbi.nlm.nih.gov/pubmed/36498860
http://dx.doi.org/10.3390/ijms232314522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735682/
https://www.ncbi.nlm.nih.gov/pubmed/36498860
http://dx.doi.org/10.3390/ijms232314522

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